A Clean Synthesis of Spiro[indoline-3,9'-xanthene]trione Derivatives

A clean and efficient synthesis of spiro[4H-pyran-oxindole] derivatives catalyzed by egg shell

Egg shell has been utilized as a natural, green, reusable and eco-friendly reagent for the synthesis of spiro[4H-pyran-oxindole] derivatives by one-pot multicomponent reaction of isatins, 1,3-diketones, and malononitrile/ ethyl cyanoacetate. Good functional group tolerance and broad scope of usable substrates are other prominent features of the present methodology.

A clean procedure for synthesis of phenylquinoline derivatives

In this investigation the reaction of cyclohexanone 1 with benzaldehyde 2 yielded (E)-2benzylidenecyclohexanone 3, which on reaction with 3-oxo-N-phenylbutanamide afforded 1-(1, 4, 5, 6, 7, 8-hexahydro-2-hydroxy-1, 4-diphenylquinolin-3-yl) ethanone.4. While the treatment of 4 with ethylbromoacetate and bromophenylethanone afforded the compounds 5 and 6 respectively. However, treatment of 4 with...

Clean and efficient synthesis of isoxazole derivatives in aqueous media.

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.

Clean and Green Synthesis of New Benzothiazole Derivatives via Electrochemical Oxidation of Catechol Derivatives

Electrochemical oxidation of the catechols 1a and 1b is studied in the presence of 6-methyl-2-thouracil (3b) and 6-propyl-2-thiouracil (3a) as nucleophiles in a phosphate buffer (0.15 mol L−1, pH = 6.8)/DMF (95:5) solution using cyclic voltammetry and controlled-potential coulometry. The results obtained indicate that the quinones derived from the catechols participate in 1,4-Michael-addition r...

European Research Conference: Organic Electrochemistry: Moving towards Clean and Selective Synthesis Industrial Synthesis of Cysteine Derivatives